Supplemental disclosure of cash flow information:
Supplemental Cash Flow Information [Abstract]
Vested (in shares)
Vested (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
Net loss
Net loss
Net Income (Loss) Attributable to Parent
Accounts Receivable
Receivable [Policy Text Block]
Entity Emerging Growth Company
Entity Emerging Growth Company
Operating lease right-of-use assets
Operating Lease, Right-of-Use Asset
Debt securities, available-for-sale
Debt Securities, Available-for-sale, Current
Income Statement Location
Income Statement Location [Axis]
Statistical Measurement
Statistical Measurement [Domain]
Entity Address, Address Line One
Entity Address, Address Line One
Shares available for grants, restricted stock units forfeited (in shares)
Share Based Compensation Arrangement By Share Based Payment Award Number Of Restricted Stock Units Forfeited
Share based compensation arrangement by share based payment award number of restricted stock units forfeited.
Weighted average grant-date fair value of options forfeited (in USD per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Additional paid-in capital
Additional Paid in Capital, Common Stock
Entity Filer Category
Entity Filer Category
Number of options, forfeited (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period
Weighted-average remaining lease term (in years)
Operating Lease, Weighted Average Remaining Lease Term
Other assets
Other Assets, Noncurrent
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
U.S. government bonds
U S Government Bonds [Member]
U.S. government bonds.
Dividend yield
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Shares available for grants, outstanding, beginning balance (in shares)
Shares available for grants, outstanding, ending balance (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant
Net increase in cash and cash equivalents
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Operating lease liabilities
Increase Decrease In Operating Lease Liabilities
Increase decrease in operating lease liabilities.
Stock-based compensation expense
APIC, Share-based Payment Arrangement, Increase for Cost Recognition
Document Fiscal Year Focus
Document Fiscal Year Focus
Transaction [Domain]
Transaction [Domain]
Other
Other Prepaid Expense And Other Assets Current
Amount of other prepaid expense and other assets current classified as other.
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Repayments of loan agreement exit fee
Payments of Financing Costs
Prepaid contract manufacturing costs
Prepaid Contract Manufacturing Costs
Prepaid contract manufacturing costs.
Variable lease payments for operating leases
Variable Lease, Cost
Anti-dilutive securities
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Weighted-average discount rate (in percent)
Operating Lease, Weighted Average Discount Rate, Percent
Schedule of Inventory
Schedule of Inventory, Current [Table Text Block]
Research and development
Research and Development Expense [Member]
Sale of Stock [Axis]
Sale of Stock [Axis]
Weighted-average grant date fair value of employee stock award grants (in USD per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Unrealized gain (loss) on available-for-sale debt securities, net
Unrealized gain/(loss) on available-for-sale debt securities, net
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Award Type
Award Type [Domain]
Stock Options
Equity Option [Member]
Credit Facility
Credit Facility [Domain]
Assets
Assets [Abstract]
Summary of Estimated Value of Cash Equivalents and Debt Securities and Gross Unrealized Holding Gains and Losses
Schedule of Available-for-sale Securities Reconciliation [Table Text Block]
Stock Options Additional Disclosures
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]
Number of options, vested and exercisable (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number
Contract manufacturing costs
Contract Manufacturing Costs Current
Contract manufacturing costs current.
Common stock available for grant (in shares)
Stock options granted (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period
Cash equivalents
Cash Equivalents [Member]
Number of options, outstanding, beginning balance (in shares)
Number of options, outstanding, ending balance (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Entity Address, City or Town
Entity Address, City or Town
Accumulated Deficit
Retained Earnings [Member]
Debt Instrument
Debt Instrument [Axis]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Inducement Plan 2021
Inducement Plan2021 [Member]
Inducement plan 2021.
Bristol-Meyers Squibb License Agreement
Product Development Agreement [Text Block]
Product development agreement.
BMS Transaction
BMS Transaction [Member]
BMS Transaction
Secured Debt
Secured Debt [Member]
Accounts receivable
Increase (Decrease) in Accounts Receivable
Cash equivalents, Amortized cost
Cash Equivalents Amortized Cost
Cash equivalents amortized cost.
Innovatus Stock Purchase Agreement
Innovatus Stock Purchase Agreement [Member]
Innovatus Stock Purchase Agreement
Short-term debt securities
Short-term Debt [Member]
Percentage of exit fee on principal balance
Debt Instrument Exit Fee Payable Percentage
Debt instrument exit fee payable percentage.
Secured Debt, Tranche C
Secured Debt, Tranche C [Member]
Tranche C.
Entity Interactive Data Current
Entity Interactive Data Current
Payment for asset purchase agreement
Payment For Asset Purchase Agreement
Payment for asset purchase agreement.
Loan agreement, remaining borrowing capacity
Line of Credit Facility, Remaining Borrowing Capacity
Number of operating segments
Number of Operating Segments
Basic (in USD per share)
Earnings Per Share, Basic
Rent expense recognized for company's operating leases
Operating Lease, Expense
2025
Lessee, Operating Lease, Liability, to be Paid, Year Three
Proceeds from sale
Proceeds from Sales of Business, Affiliate and Productive Assets
Unvested shares, beginning balance (in shares)
Unvested shares, ending balance (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Document Type
Document Type
Schedule of Product Information [Table]
Schedule of Product Information [Table]
Income related to asset purchase agreement
Income Loss Related To Asset Purchase Agreement
Income (loss) related to asset purchase agreement.
Entity Current Reporting Status
Entity Current Reporting Status
Commercial paper
Commercial Paper [Member]
Operating cash outflows for operating lease liabilities
Operating Lease, Payments
Number of shares available to be issued (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized
Accounts receivable, net
Receivables, Net, Current
Bad debt expense
Accounts Receivable, Credit Loss Expense (Reversal)
Plan Name
Plan Name [Axis]
Financial assets:
Assets, Fair Value Disclosure [Abstract]
Total debt, net
Long-term Debt
Financial assets
Assets, Fair Value
Assets, Fair Value Disclosure
Level 1
Fair Value, Inputs, Level 1 [Member]
Investing activities
Net Cash Provided by (Used in) Investing Activities [Abstract]
Development And Regulatory Milestones
Development And Regulatory Milestones [Member]
Development And Regulatory Milestones
Document Transition Report
Document Transition Report
Other-than-temporary impairment losses
Other than Temporary Impairment Losses, Investments
Weighted-average common shares outstanding:
Earnings Per Share, Basic and Diluted, Other Disclosures [Abstract]
Income Tax Disclosure [Abstract]
Income Tax Disclosure [Abstract]
Total liabilities and stockholders’ equity
Liabilities and Equity
Other
Other Accrued Liabilities, Current
Transaction Type [Axis]
Transaction Type [Axis]
Early access program term (in years)
Early Access Program Term
Early Access Program Term
Proceeds from maturities of debt securities available-for-sale
Proceeds from Sale and Maturity of Debt Securities, Available-for-sale
Weighted-average exercise price, exercised (in USD per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Liabilities and Stockholders’ Equity
Liabilities and Equity [Abstract]
Accounts payable
Increase (Decrease) in Accounts Payable
Commercial Sales
Commercial Sales [Member]
Commercial Sales
Description of Business
Business Description and Basis of Presentation [Text Block]
Milestone obligations
Milestone Obligations
Milestone Obligations
Net Loss Per Share
Earnings Per Share [Text Block]
Cash and Cash Equivalents
Cash and Cash Equivalents [Domain]
Issuance of common stock upon exercise of stock options
Stock Issued During Period, Value, Stock Options Exercised
Minimum
Minimum [Member]
Variable Rate Component [Domain]
Variable Rate Component [Domain]
Variable Rate Component [Domain]
2024
Lessee, Operating Lease, Liability, to be Paid, Year Two
Loan outstanding
Long-term Line of Credit
Selling, general and administrative
Selling, General and Administrative Expense
Debt securities, Unrealized gain
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax
Debt securities, unrealized loss position for more than 12 months
Debt Securities, Available-for-sale, Continuous Unrealized Loss Position, 12 Months or Longer
Trading Symbol
Trading Symbol
Compensation and related benefits
Accrued Employee Benefits, Current
Current liabilities:
Liabilities, Current [Abstract]
Issuance of common stock
Value of common stock issued during period
Stock Issued During Period, Value, New Issues
Revenue Recognition
Revenue [Policy Text Block]
Debt
Debt Disclosure [Text Block]
Weighted-average exercise price, vested and exercisable (in USD per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Issuance of common stock upon release of restricted stock units
Stock Issued During Period, Value, Restricted Stock Award, Gross
Line of Credit
Line of Credit [Member]
Stock-Based Compensation
Share-based Payment Arrangement [Text Block]
Shares available for grants, performance stock units granted (in shares)
Share Based Compensation Arrangement By Share Based Payment Award Number Of Performance Stock Units Granted
Share based compensation arrangement by share based payment award number of performance stock units granted.
Innovatus Loan
Innovatus Loan [Member]
Innovatus Loan
Level 3
Fair Value, Inputs, Level 3 [Member]
Accounting Policies [Abstract]
Accounting Policies [Abstract]
Weighted average remaining contractual life, beginning balance (in years)
Weighted average remaining contractual life, ending balance (in years)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Prepaid expenses and other current assets
Increase Decrease In Prepaid Expenses And Other Current Assets
Increase decrease in prepaid expenses and other current assets.
Common stock offering costs
Payments of Stock Issuance Costs
Issuance of common stock (in shares)
Issuance of common stock (in shares)
Stock Issued During Period, Shares, New Issues
Performance Stock Units (PSU)
Performance Stock Units P S U [Member]
Performance stock units PSU member.
Present value of future lease payments
Operating Lease, Liability
Common stock
Common Stock, Value, Issued
Weighted-average period for recognition (in years)
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Weighted average grant-date fair value of options beginning balance (in USD per share)
Weighted average grant-date fair value of options ending balance (in USD per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Basis of Presentation
Basis of Accounting, Policy [Policy Text Block]
Commitments and Contingencies
Lessee, Operating Leases [Text Block]
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accounts receivable, allowance for doubtful accounts
Accounts Receivable, Allowance for Credit Loss, Current
Schedule of Prepaid Expenses and Other Current Assets
Schedule Of Prepaid Expenses And Other Current Assets Table [Text Block]
The tabular disclosure of prepaid expenses and other current assets.
Inventory write down
Inventory Write-down
Remaining in 2022
Lessee, Operating Lease, Liability, to be Paid, Remainder of Fiscal Year
Payment of debt issuance costs
Payments of Debt Issuance Costs
Other Commitments [Table]
Other Commitments [Table]
Weighted-average assumptions used in Black-Scholes Model to estimate fair value of stock options granted
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Contract research costs
Accrued Contracted Research Costs Current
Accrued contracted research costs current.
Purchase Agreement
Purchase Agreement [Member]
Purchase Agreement
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Document Period End Date
Document Period End Date
Total costs and operating expenses
Costs and Expenses
Debt Securities
Marketable Securities, Policy [Policy Text Block]
Entity Registrant Name
Entity Registrant Name
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Less: imputed interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Palo Alto, California
CALIFORNIA
Shares available for grants, granted (in shares)
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Options Granted
Share based compensation arrangement by share based payment award number of shares available for grant options granted.
Work-in-progress
Inventory, Work in Process, Net of Reserves
Variable Rate Component Two
Variable Rate Component Two [Member]
Variable Rate Component Two
Prepaid expenses and other current assets
Total prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Financial Instrument
Financial Instrument [Axis]
Selling, general and administrative
Selling, General and Administrative Expenses [Member]
Accrued liabilities
Total accrued liabilities
Accrued Liabilities, Current
Shares available for grants, forfeited (in shares)
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Forfeited
Share based compensation arrangement by share based payment award number of shares available for grant forfeited.
Finished goods
Inventory, Finished Goods, Net of Reserves
Stock Options
Share-based Payment Arrangement, Option [Member]
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Axis]
Payments related to priority review voucher
Payments Related To Priority Review Voucher
Payments related to priority review voucher.
Common Stock
Common Stock [Member]
Interest income
Investment Income, Interest
Loss from operations
Operating Income (Loss)
Current portion of operating lease liabilities
Less: current portion of operating lease liabilities
Operating Lease, Liability, Current
Debt securities, unrealized loss
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Stock-based compensation
Share-based Payment Arrangement, Noncash Expense
Long-term debt securities
Long-term Debt [Member]
Autorisation Temporaire D Utlisation Member
Autorisation Temporaire D Utlisation Member [Member]
Autorisation Temporaire D Utlisation Member
Additional Paid-In Capital
Additional Paid-in Capital [Member]
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Long-term Debt, Type [Domain]
Long-term Debt, Type [Domain]
Accrued liabilities
Increase (Decrease) in Accrued Liabilities
Purchase of debt securities available-for-sale
Payments to Acquire Debt Securities, Available-for-sale
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Income taxes paid
Income Taxes Paid
Borrowings from loan agreement
Proceeds from Lines of Credit
Other (expense) income, net
Other Nonoperating Income (Expense)
Principal and interest payment period
Debt Instrument Principal And Interest Payment Period
Debt instrument principal and interest payment period.
Progeria Research Foundation (PRF) Collaboration Agreement
P R F Collaboration Agreement [Member]
PRF collaboration agreement .
Prepaid insurance
Prepaid Insurance
Purchase of property and equipment
Payments to Acquire Property, Plant, and Equipment
Maximum
Maximum [Member]
Share-based Payment Arrangement [Abstract]
Share-based Payment Arrangement [Abstract]
Amended Oxford Loan
Amended Oxford Loan [Member]
Amended Oxford loan.
Total liabilities
Liabilities
Raw materials
Inventory, Raw Materials, Net of Reserves
Schedule of Components of Accrued Liabilities
Schedule of Accrued Liabilities [Table Text Block]
Award Type
Award Type [Axis]
Weighted-average exercise price, granted (in USD per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Financing activities
Net Cash Provided by (Used in) Financing Activities [Abstract]
Aggregate intrinsic value, beginning balance
Aggregate intrinsic value, ending balance
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Other revenue
Other Revenue [Member]
Other Revenue
Maturity of Operating Leases Liabilities and Future Minimum Lease Payments
Lessee, Operating Lease, Liability, Maturity [Table Text Block]
Total stockholders’ equity
Balance, beginning of period
Balance, end of period
Stockholders' Equity Attributable to Parent
Balance Sheet Related Disclosures [Abstract]
Balance Sheet Related Disclosures [Abstract]
Gain from sale of priority review voucher
Gain Loss From Sale Of Priority Review Voucher
Gain (loss) from sale of priority review voucher.
Loss on extinguishment of debt
Gain (Loss) on Extinguishment of Debt
Up front cash payments
Up Front Cash Payments
Up Front Cash Payments
Stockholders’ equity:
Stockholders' Equity Attributable to Parent [Abstract]
Risk free interest rate, minimum
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Operating lease liabilities
Operating Lease, Liability, Noncurrent
Face value of term loan
Face value of debt
Debt Instrument, Face Amount
Interest expense
Interest expense
Interest Expense
Licensing Agreements
Licensing Agreements [Member]
Common stock issued under Product Development Agreement
Issuance of Stock and Warrants for Services or Claims
Volatility, maximum
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Stock issuance costs
Stock Issuance Costs
Stock Issuance Costs
Proceeds from sale of priority review voucher
Proceeds From Sale Of Priority Review Voucher
Proceeds from sale of priority review voucher.
City Area Code
City Area Code
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Restricted Stock Units (RSU)
Restricted stock units (unvested)
Restricted Stock Units (RSUs) [Member]
Statement of Stockholders' Equity [Abstract]
Statement of Stockholders' Equity [Abstract]
Issuance of common stock upon ESPP purchase (in shares)
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Income Statement [Abstract]
Income Statement [Abstract]
Amendment Flag
Amendment Flag
Secured Debt, Amended Tranche B
Amended Tranche B [Member]
Amended tranche B.
Proceeds from issuance of common stock upon stock option exercises
Proceeds from Stock Options Exercised
Asset Purchase Agreement
Asset Purchase Agreement [Text Block]
The entire disclosure for asset purchase agreement and related license agreements.
Issuance of common stock upon release of restricted stock units (in shares)
Stock Issued During Period, Shares, Restricted Stock Award, Gross
Weighted-average exercise price, forfeited (in USD per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Finite-Lived Intangible Assets by Major Class
Finite-Lived Intangible Assets by Major Class [Axis]
Provision for income taxes
Income Tax Expense (Benefit)
Proceeds from debt
Proceeds from Issuance of Long-term Debt
Equity Components
Equity Components [Axis]
Fair Value Disclosures [Abstract]
Fair Value Disclosures [Abstract]
Antidilutive Securities
Antidilutive Securities [Axis]
Total current assets
Assets, Current
Total undiscounted payments
Lessee, Operating Lease, Liability, to be Paid
Sale of Stock [Domain]
Sale of Stock [Domain]
Forfeited (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Inventories
Total inventories
Inventory, Net
Entity File Number
Entity File Number
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Statement of Financial Position [Abstract]
Statement of Financial Position [Abstract]
Debt, current portion
Less: current portion of debt
Long-term Debt, Current Maturities
Product and Service [Axis]
Product and Service [Axis]
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Entity Small Business
Entity Small Business
Minimum cash balance of face value of loan (in percent)
Minimum Cash Balance Of Face Value Of Loan, Percent
Minimum Cash Balance Of Face Value Of Loan, Percent
Weighted-average grant date fair value of employee option grants (in USD per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Equity Component
Equity Component [Domain]
2023
Lessee, Operating Lease, Liability, to be Paid, Year One
Secured Debt, Tranche B and C
Secured Debt, Tranche B and C [Member]
Secured Debt, Tranche B and C
Capitalized debt issuance costs
Debt Issuance Costs, Gross
Variable Rate Component One
Variable Rate Component One [Member]
Variable Rate Component One
Statement [Line Items]
Statement [Line Items]
AbbVie Asset Purchase Agreement
Abbvie Asset Purchase Agreement [Member]
Abbvie asset purchase agreement.
Weighted- Average Exercise Price
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Debt securities, Estimated Fair Value
Debt Securities, Available-for-sale
Debt Disclosure [Abstract]
Debt Disclosure [Abstract]
Entity Address, State or Province
Entity Address, State or Province
Fifth Amended Oxford Loan
Oxford Loan Fifth Amendment [Member]
Oxford loan fifth amendment.
Level 2
Fair Value, Inputs, Level 2 [Member]
ESPP
Employee Stock Purchase Plan [Member]
Employee Stock Purchase Plan [Member].
Amended Tranche A
Secured Debt, Amended Tranche A [Member]
Amended tranche A.
Debt securities, Amortized cost
Debt Securities, Available-for-sale, Amortized Cost
Proceeds related to asset purchase agreement
Proceeds Related To Asset Purchase Agreement
Proceeds related to asset purchase agreement.
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Number of options, granted (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Entity Shell Company
Entity Shell Company
Amendment fees payment
Amendment Fees Payment
Amendment fees payment.
Local Phone Number
Local Phone Number
Summary of Non-cash Stock Based Compensation Expense
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Issuance of common stock upon offering at-the-market, net of commissions
Proceeds from Issuance of Common Stock
Total assets
Assets
Product revenue reserves
Product Revenue Reserves
Product revenue reserves.
Plan Name
Plan Name [Domain]
Interest paid
Interest Paid, Excluding Capitalized Interest, Operating Activities
Geographical
Geographical [Domain]
Schedule of Nonvested Restricted Stock Units and Performance Stock Units Activity and Weighted Average Grant Date Fair Value
Schedule of Nonvested Restricted Stock Units Activity [Table Text Block]
Research and development
Research and Development Expense
Product and Service [Domain]
Product and Service [Domain]
Balance Sheet Components
Supplemental Balance Sheet Disclosures [Text Block]
Issuance of common stock to lender (in shares)
Stock Issued During Period, Shares, Stock Issued To Lender
Stock Issued During Period, Shares, Stock Issued To Lender
Restricted Stock Units and Performance Stock Unit
Restricted Stock Units And Performance Stock Unit [Member]
Restricted stock units and performance stock unit member.
Lease renewal term
Lessee, Operating Lease, Renewal Term
Long-term debt securities
Debt Securities, Noncurrent
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Accrued Research and Development Costs
Accrued Research And Development Costs [Policy Text Block]
Accrued research and development costs.
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Net cash used in operating activities
Net Cash Provided by (Used in) Operating Activities
Schedule of Long-Term Debt and Unamortized Discount Balances
Schedule of Debt [Table Text Block]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value, Recurring and Nonrecurring [Table]
Debt Instrument [Table]
Schedule of Long-term Debt Instruments [Table]
Entity Tax Identification Number
Entity Tax Identification Number
Geographical
Geographical [Axis]
Security deposit of collateral for lease
Pledged Assets Separately Reported, Securities Pledged as Collateral, at Fair Value
Loan final repayment exit fees payable
Exit fee
Debt Instrument Unamortized Exit Fees
Debt instrument unamortized exit fees.
Basic (in shares)
Weighted Average Number of Shares Outstanding, Basic
Diluted (in USD per share)
Earnings Per Share, Diluted
Non-cash interest expense
Amortization of Debt Issuance Costs and Discounts
Sale of common stock (in USD per share)
Sale of Stock, Price Per Share
Amortization of operating lease right-of-use assets
Operating Lease, Right-of-Use Asset, Amortization Expense
Product revenue, net
Product [Member]
Financial liabilities
Financial Liabilities Fair Value Disclosure
Development Phase Two [Domain]
Development Phase Two [Domain]
Development Phase Two
Issuance of common stock to lender
Stock Issued During Period, Value, Stock Issued To Lender
Stock Issued During Period, Value, Stock Issued To Lender
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Cost of sales
Cost of Revenue
Asset Purchase Agreement And Related License Agreement [Line Items]
Asset Purchase Agreement And Related License Agreement [Line Items]
Asset purchase agreement and related license agreement.
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Other comprehensive loss:
Other Comprehensive Income (Loss), Net of Tax [Abstract]
Short-term debt securities
Debt Securities, Current
Corporate debt securities
Corporate Debt Securities [Member]
Fair Value Measurements
Fair Value Disclosures [Text Block]
Accounts payable
Accounts Payable, Current
Cash Equivalents And Investment Securities [Table]
Cash Equivalents And Investment Securities [Table]
Cash equivalents and investment securities.
Depreciation and amortization
Depreciation, Depletion and Amortization
Shares Available for Grants
Shares Available for Grant [Abstract]
Shares Available for Grant
Summary of Assets and Liabilities Measured at Fair Value
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Accumulated Other Comprehensive Income (Loss)
AOCI Attributable to Parent [Member]
Inventories
Increase (Decrease) in Inventories
Interest payment period
Debt Instrument Interest Payment Period
Debt instrument interest payment period.
Balance, beginning of period (in shares)
Balance, end of period (in shares)
Common Stock, Shares, Outstanding
Financial Instruments
Financial Instruments [Domain]
Product Development Agreement [Abstract]
Product Development Agreement [Abstract]
Product development agreements.
Prepaid marketing
Prepaid Marketing
Prepaid Marketing
Revenues [Abstract]
Revenues [Abstract]
Debt Instrument, percent of interest due (in percent)
Debt Instrument, Percent Of Interest Due
Debt Instrument, Percent Of Interest Due
Asset Purchase Agreements And Related License Agreements [Abstract]
Asset Purchase Agreements And Related License Agreements [Abstract]
Asset purchase agreements and related license agreements.
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Effective tax rate
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
Income Statement Location
Income Statement Location [Domain]
Shares available for grants, additional options authorized (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized
Variable Rate Component [Axis]
Variable Rate Component [Axis]
Variable Rate Component
Property and equipment, net
Property, Plant and Equipment, Net
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Repayment of debt
Repayments of Long-term Debt
Earnings Per Share [Abstract]
Earnings Per Share [Abstract]
Document Quarterly Report
Document Quarterly Report
Total revenue
Revenues
Secured Debt, Tranche A
Secured Debt, Tranche A [Member]
Secured Debt, Tranche A
Other Commitments [Line Items]
Other Commitments [Line Items]
Weighted-average exercise price, outstanding, beginning balance (in USD per share)
Weighted-average exercise price, outstanding, ending balance (in USD per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Costs and operating expenses:
Costs and Expenses [Abstract]
Debt, net of current portion
Carrying value of debt
Long-term Debt, Excluding Current Maturities
Number of Options
Share-based Compensation Arrangement by Share-based Payment Award, Options, Number Of Shares Outstanding [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Number Of Shares Outstanding
Stock-based compensation expense
Total stock-based compensation expense
Share-based Payment Arrangement, Expense
Cost of Sales
Cost of Goods and Service [Policy Text Block]
Weighted average remaining contractual life, vested and exercisable (in years)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Net loss per common share:
Earnings Per Share, Basic and Diluted [Abstract]
Weighted-Average
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Volatility, minimum
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Document Fiscal Period Focus
Document Fiscal Period Focus
Amendment
Oxford Loan Amendment [Member]
Oxford loan amendment.
Amortization of debt securities premiums and discounts
Accretion (Amortization) of Discounts and Premiums, Investments
Other final payments
Line of Credit Facility, Other Final Payments
Line of Credit Facility, Other Final Payments
Aggregate intrinsic value, vested and exercisable
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value
Cash and cash equivalents at beginning of period
Cash and cash equivalents at end of period
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents
Options to purchase common stock
Options Granted To Employees And Non Employees [Member]
Options granted to employees and non employees.
Sale of common stock, shares issued (in shares)
Sale of Stock, Number of Shares Issued in Transaction
Product Information [Line Items]
Product Information [Line Items]
Development Phase Three
Development Phase Three [Member]
Development Phase Three
Secured Debt, Tranche B
Secured Debt, Tranche B [Member]
Tranche B.
Risk free interest rate, maximum
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
Cash Equivalents and Investment Securities [Line Items]
Cash Equivalents And Investment Securities [Line Items]
Cash equivalents and investment securities.
Statement of Comprehensive Income [Abstract]
Statement of Comprehensive Income [Abstract]
Current assets:
Assets, Current [Abstract]
Leases [Abstract]
Prepaid research costs
Prepaid Research Costs
Amount of consideration paid in advance for research that provides economic benefits within a future period of one year or the normal operating cycle, if longer.
Entity Central Index Key
Entity Central Index Key
Security Exchange Name
Security Exchange Name
Cash equivalents, Estimated Fair Value
Cash and Cash Equivalents, Fair Value Disclosure
Issuance of common stock upon exercise of stock options (in shares)
Number of options, exercised (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Diluted (in shares)
Weighted Average Number of Shares Outstanding, Diluted
Loan final repayment additional exit fees payable
Debt Instrument Unamortized Additional Exit Fees
Debt instrument unamortized additional exit fees.
Income Taxes
Income Tax Disclosure [Text Block]
Cash, cash equivalents and short-term investments
Cash, Cash Equivalents, and Short-term Investments
Long-term Debt, Type [Axis]
Long-term Debt, Type [Axis]
Current Fiscal Year End Date
Current Fiscal Year End Date
Stock Option Activity
Share-based Payment Arrangement, Option, Activity [Table Text Block]
Minimum prime rate
Debt Instrument, Basis Spread on Variable Rate
Debt discount
Debt Instrument, Unamortized Discount, Current
Accrued and unpaid interest
Line of Credit Facility, Increase, Accrued Interest
Summary of Potentially Dilutive Shares Excluded from Computation of Diluted Net Loss Per Share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Statement of Cash Flows [Abstract]
Statement of Cash Flows [Abstract]
Credit Facility
Credit Facility [Axis]
Finite-Lived Intangible Assets, Major Class Name
Finite-Lived Intangible Assets, Major Class Name [Domain]
Net cash (used in) provided by investing activities
Net Cash Provided by (Used in) Investing Activities
Change in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Issuance of common stock upon ESPP purchase
Stock Issued During Period, Value, Employee Stock Purchase Plan
Operating activities
Net Cash Provided by (Used in) Operating Activities [Abstract]
Weighted average grant-date fair value of options vested (in USD per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Effective interest rate
Debt Instrument, Interest Rate During Period
Oxford Loan
Oxford Loan [Member]
Oxford loan.
Expected term (in years)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
Total current liabilities
Liabilities, Current
Transfers in or out of level 3
Fair Value Transfers Between Levels Transfers Amount
Fair value transfers between levels transfers amount.
Loan agreement, aggregate borrowing capacity
Line of Credit Facility, Maximum Borrowing Capacity
Money market funds
Money Market Funds [Member]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Unamortized debt discount associated with exit fee, debt issuance costs and loan origination fees
Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net
Debt Instrument, Name
Debt Instrument, Name [Domain]
Title of 12(b) Security
Title of 12(b) Security
Proceeds from issuance of common stock upon ESPP purchase
Proceeds from Stock Plans
Statement [Table]
Statement [Table]
RSU and PSU Roll Forward Activity
Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Outstanding [Roll Forward]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Recent Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Other assets
Increase (Decrease) in Other Noncurrent Assets
Total unrecognized compensation expense
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Asset Purchase Agreement And Related License Agreement [Table]
Asset Purchase Agreement And Related License Agreement [Table]
Asset Purchase Agreement And Related License Agreement [Table]
Short term deposits
Deposits Assets, Current
Statistical Measurement
Statistical Measurement [Axis]
Cover [Abstract]
Cover [Abstract]
Vesting of common stock issued under Product Development Agreement
Stock Issued During Period Value Product Development Agreement
Stock issued during period value product development agreement.
Inventories
Inventory, Policy [Policy Text Block]
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Shares available for grants, restricted stock units granted (in shares)
Share Based Compensation Arrangement By Share Based Payment Award Number Of Restricted Stock Units Granted
Share based compensation arrangement by share based payment award number of restricted stock units granted.
Total leased space
Land Subject to Ground Leases
Cash and Cash Equivalents
Cash and Cash Equivalents [Axis]
Proceeds from issuance of common stock to lender
Proceeds From Issuance Of Common Stock In Connection With Debt
Proceeds From Issuance Of Common Stock In Connection With Debt
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]