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Your Vote Counts! EIGER BIOPHARMACEUTICALS, INC. 2021 Annual Meeting Vote by June 13, 2021 11:59 PM ET EIGER BIOPHARMACEUTICALS, INC. 2155 PARK BOULEVARD PALO ALTO, CA 94306 D43861-P52768 You invested in EIGER BIOPHARMACEUTICALS, INC. and its time to vote! You have the right to vote on proposals being presented at the Annual Meeting. This is an important notice regarding the availability of proxy materials for the stockholder meeting to be held on June 14, 2021. Get informed before you vote View the Notice and Proxy Statement and Form 10-K online OR you can receive a free paper or email copy of the material(s) by requesting prior to May 31, 2021. If you would like to request a copy of the material(s) for this and/or future stockholder meetings, you may (1) visit, (2) call 1-800-579-1639 or (3) send an email to [email protected] If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. For complete information and to vote, visit Control # Vote Virtually at the Meeting* June 14, 2021 10:00 AM, PDT Smartphone users Point your camera here and vote without entering a control number Vote Virtually at the Meeting: To vote during the Meeting go to Have the control number that is printed in the box available and follow the instructions. Vote Before the Meeting by Internet: To vote now by internet, go to Have the control number that is printed in the box available and follow the instructions. Vote Before the Meeting By Mail: You can vote by mail by requesting a paper copy of the materials, which will include a proxy card. *Please check the meeting materials for any special requirements for meeting attendance. V1


Vote at THIS IS NOT A VOTABLE BALLOT This is an overview of the proposals being presented at the upcoming stockholder meeting. Please follow the instructions on the reverse side to vote these important matters. Board Recommends Voting Items 1. Election of Thomas Dietz and Kim Sablich as Class III Directors of the Company, as recommended for nomination by the Nominating and Governance Committee and approved by the Board, to hold office until the 2024 Annual Meeting of Stockholders and until his or her successor is duly elected and qualified, or until his or her earlier death, resignation or removal; Nominees: For 01) Thomas Dietz 02) Kim Sablich For 2. Approval, on an advisory basis, of the compensation of the Companys named executive officers; 3. Ratification of the Audit Committees selection of KPMG LLP as the Companys independent registered public accounting firm for the year ending December 31, 2021; and For 4. Any other business properly brought before the 2021 Annual Meeting. Prefer to receive an email instead? While voting on, be sure to click Sign up for E-delivery. D43862-P52768