Eiger BioPharmaceuticals Announces Results from Multiple Presentations at the European Association for the Study of the Liver (EASL) International Liver Congress™ 2022
"We are pleased that EASL recognized our HDV platform with multiple presentations this year highlighting both the lonafarnib and peginterferon lambda programs," said
Abstract #3442: Clinical Features Predictive of Cirrhosis in a Large Cohort of Patients with Chronic Hepatitis Delta Infection - Insights from the D-LIVR Trial; Etzion, O., Asselah, T., Lampertico, P. et al.
Conclusions: In the on-going Phase 3 D-LIVR study, the largest cohort to date of patients with chronic HDV, alarmingly high rates of cirrhosis were seen among patients with compensated liver disease at a relatively young mean age. Over 40% of cirrhotic patients were ≤ 45 years old. A high index of suspicion for cirrhosis should be maintained in this population, especially in older patients and in those showing subtle changes in markers of synthetic liver function and portal hypertension.
Abstract #2072: Mathematical Modeling of HDV RNA Kinetics Suggests High Peginterferon Lambda Efficacies in Blocking Viral Production and Infection: Insights from the LIMT-1 Study; Cardozo-Ojeda, E.F., Etzion, O. et al.
Conclusions: Previously reported end of study data of Phase 2 LIMT-1 trial of peginterferon lambda (Lambda) monotherapy showed that Lambda therapy had better antiviral activity and tolerability compared to historical data for peginterferon alfa and identified four main HDV RNA kinetic patterns under Lambda therapy. This study provides, for the first time, a dynamic description of HDV response under Lambda monotherapy. Lambda blocks viral production with high efficacy. HDV kinetics depend on Lambda efficacy, the baseline fraction of noninfected hepatocytes and their proliferation rates.
Abstract #1904: Lonafarnib Combination with Peginterferon Lambda Diminished Triphasic HDV Kinetic Pattern Seen Under Lambda Monotherapy: the LIFT-1 HDV Study; Duehren, S., Dahari, H., Heller, T. et al.
Conclusions: End of study data of Phase 2 LIFT-1 study of peginterferon lambda combined with lonafarnib was previously reported (AASLD 2020). The goal of the current study was to characterize HDV RNA, HBV DNA, HBsAg and ALT kinetics during and after combination therapy. Combination therapy was associated with better treatment success (≥ 2 log decline HDV RNA) compared to Lambda monotherapy. No null responders with Lambda + Lonafarnib. Reduction of the triphasic kinetic pattern suggests that the addition of Lonafarnib may decrease production/release of HDV RNA. Kinetic patterns observed in Lambda + Lonafarnib and Lambda monotherapy are associated with treatment response.
For additional information about
This press release contains forward-looking statements within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. All statements other than statements of historical facts, including statements regarding our future financial condition, timing for and outcomes of clinical results, regulatory objectives, business strategy and plans and objectives for future operations, are forward-looking statements. Forward-looking statements are our current statements regarding our intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things, our anticipated significant milestones in 2022; the timing of our ongoing and planned clinical development; the sufficiency of our cash, cash equivalents and investments to fund our operations; expectations regarding the timing and availability of topline data from our Phase 3 D-LIVR study in HDV; our ability to finance the continued advancement of our development pipeline products; and the potential for success of any of our product candidates. Various important factors could cause actual results or events to differ materially from the forward-looking statements that
Wheelhouse Life Science Advisors
SVP, Corporate Affairs
View original content to download multimedia:https://www.prnewswire.com/news-releases/eiger-biopharmaceuticals-announces-results-from-multiple-presentations-at-the-european-association-for-the-study-of-the-liver-easl-international-liver-congress-2022-301576119.html