Eiger Announces Abstracts Highlighting Peginterferon Lambda and Lonafarnib in Chronic Hepatitis Delta Virus (HDV) Infection Accepted for Presentation at The Liver Meeting Digital Experience™ 2020
- Late-Breaking Oral Presentation L08: A Phase 2 Study of Peginterferon Lambda, Lonafarnib, and Ritonavir for 24 Weeks: End-Of-Study Results from the LIFT HDV Study. Presented by
Christopher Koh, MD, MHSc FAASLD, Liver Disease Branch, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health.
- Late Breaking Poster LP24: Noninvasive Tests for Detection of Biopsy-Proven Cirrhosis in Chronic Hepatitis D Infected Patients Are Suboptimal. Presented by
Ohad Etzion, MD, Faculty of Health Sciences, Ben-Gurion Universityof the Negev; Director, Department of Gastroenterology and Liver Diseases, Soroka University Medical Center.
- Poster 1027: Regression of Liver Fibrosis Following 48 Weeks of Therapy With Peginterferon Lambda in Patients with Chronic Hepatitis Delta Virus (HDV) Infection. Presented by
David Yardeni, MD, Gastroenterology and Liver Diseases, Soroka University Medical Center; Faculty of Health Sciences, Ben-Gurion Universityof the Negev.
About Peginterferon Lambda (Lambda)
Lambda is a well-characterized, first in class, type III interferon (IFN) that stimulates immune responses that are critical for the development of host protection during viral infections. Lambda targets type III IFN receptors which are distinct from the type I IFN receptors targeted by IFN alfa. Lambda type III receptors are highly expressed on hepatocytes with limited expression on hematopoietic and central nervous system cells, which may reduce off-target effects and improve tolerability of Lambda.
Lambda is Phase 3 ready in development as a treatment for HDV. Eiger has received Orphan Designation by the
Lonafarnib is a well-characterized, late-stage, oral inhibitor of farnesyl transferase, an enzyme involved in modification of proteins through a process called prenylation, a vital process in the life cycle of HDV. Blocking prenylation of the large delta hepatitis antigen (LDHAg) reduces HDV replication.
Lonafarnib has been dosed in over 150 HDV-infected patients across international academic centers and is in Phase 3 global, pivotal trial (D-LIVR Study). Lonafarnib has been granted Orphan Drug designation by the
Eiger is a late-stage biopharmaceutical company focused on the development and commercialization of first-in-class, well-characterized drugs for serious rare and ultra-rare diseases for patients with high unmet medical needs.
Eiger's lead clinical programs target Hepatitis Delta Virus (HDV) infection, the most serious form of human viral hepatitis. Eiger is developing two complementary treatments for HDV. Lonafarnib is a first-in-class, oral prenylation inhibitor in a global Phase 3 trial. Peginterferon lambda is a first-in-class, well-tolerated type III interferon entering Phase 3.
Eiger has filed an NDA and MAA for lonafarnib for the treatment of Hutchinson-Gilford Progeria Syndrome (HGPS or Progeria) and Progeroid Laminopathies. FDA PDUFA date is
For additional information about Eiger and its clinical programs, please visit www.eigerbio.com.
Note Regarding Forward-Looking Statements
This press release contains "forward-looking" statements that involve substantial risks and uncertainties. All statements other than statements of historical facts, including statements regarding our future financial condition, timing for and outcomes of clinical results, business strategy and plans and objectives for future operations, are forward-looking statements. These forward-looking statements include terminology such as "believe," "will," "may," "estimate," "continue," "anticipate," "contemplate," "intend," "target," "project," "should," "plan," "expect," "predict," "could," "potentially" or the negative of these terms. Forward-looking statements are our current statements regarding our intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things, our anticipating significant milestones in 2020 and 2021, the timing of our ongoing and planned clinical development, including the potential for approval of our lonafarnib product candidate in the
Various important factors could cause actual results or events to differ materially from the forward-looking statements that Eiger makes, including additional applicable risks and uncertainties described in the "Risk Factors" sections in the Quarterly Report on Form 10-Q for the quarter ended
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